diff --git a/relay/adaptor/anthropic/main.go b/relay/adaptor/anthropic/main.go
index 04260723..a0fa7f98 100644
--- a/relay/adaptor/anthropic/main.go
+++ b/relay/adaptor/anthropic/main.go
@@ -39,6 +39,15 @@ func stopReasonClaude2OpenAI(reason *string) string {
 	}
 }
 
+// isModelSupportThinking is used to check if the model supports extended thinking
+func isModelSupportThinking(model string) bool {
+	if strings.Contains(model, "claude-3-7-sonnet") {
+		return true
+	}
+
+	return false
+}
+
 func ConvertRequest(c *gin.Context, textRequest model.GeneralOpenAIRequest) (*Request, error) {
 	claudeTools := make([]Tool, 0, len(textRequest.Tools))
 
@@ -67,14 +76,16 @@ func ConvertRequest(c *gin.Context, textRequest model.GeneralOpenAIRequest) (*Re
 		Thinking:    textRequest.Thinking,
 	}
 
-	if c.Request.URL.Query().Has("thinking") && claudeRequest.Thinking == nil {
+	if isModelSupportThinking(textRequest.Model) &&
+		c.Request.URL.Query().Has("thinking") && claudeRequest.Thinking == nil {
 		claudeRequest.Thinking = &model.Thinking{
 			Type:         "enabled",
 			BudgetTokens: int(math.Min(1024, float64(claudeRequest.MaxTokens/2))),
 		}
 	}
 
-	if claudeRequest.Thinking != nil {
+	if isModelSupportThinking(textRequest.Model) &&
+		claudeRequest.Thinking != nil {
 		if claudeRequest.MaxTokens <= 1024 {
 			return nil, fmt.Errorf("max_tokens must be greater than 1024 when using extended thinking")
 		}
diff --git a/relay/adaptor/aws/claude/main.go b/relay/adaptor/aws/claude/main.go
index 69251c3d..762f5ba6 100644
--- a/relay/adaptor/aws/claude/main.go
+++ b/relay/adaptor/aws/claude/main.go
@@ -49,13 +49,14 @@ func awsModelID(requestModel string) (string, error) {
 }
 
 func Handler(c *gin.Context, awsCli *bedrockruntime.Client, modelName string) (*relaymodel.ErrorWithStatusCode, *relaymodel.Usage) {
-	awsModelId, err := awsModelID(c.GetString(ctxkey.RequestModel))
+	awsModelID, err := awsModelID(c.GetString(ctxkey.RequestModel))
 	if err != nil {
 		return utils.WrapErr(errors.Wrap(err, "awsModelID")), nil
 	}
 
+	awsModelID = utils.ConvertModelID2CrossRegionProfile(awsModelID, awsCli.Options().Region)
 	awsReq := &bedrockruntime.InvokeModelInput{
-		ModelId:     aws.String(awsModelId),
+		ModelId:     aws.String(awsModelID),
 		Accept:      aws.String("application/json"),
 		ContentType: aws.String("application/json"),
 	}
diff --git a/relay/adaptor/aws/llama3/main.go b/relay/adaptor/aws/llama3/main.go
index e5fcd89f..aff3e0cf 100644
--- a/relay/adaptor/aws/llama3/main.go
+++ b/relay/adaptor/aws/llama3/main.go
@@ -70,13 +70,14 @@ func ConvertRequest(textRequest relaymodel.GeneralOpenAIRequest) *Request {
 }
 
 func Handler(c *gin.Context, awsCli *bedrockruntime.Client, modelName string) (*relaymodel.ErrorWithStatusCode, *relaymodel.Usage) {
-	awsModelId, err := awsModelID(c.GetString(ctxkey.RequestModel))
+	awsModelID, err := awsModelID(c.GetString(ctxkey.RequestModel))
 	if err != nil {
 		return utils.WrapErr(errors.Wrap(err, "awsModelID")), nil
 	}
 
+	awsModelID = utils.ConvertModelID2CrossRegionProfile(awsModelID, awsCli.Options().Region)
 	awsReq := &bedrockruntime.InvokeModelInput{
-		ModelId:     aws.String(awsModelId),
+		ModelId:     aws.String(awsModelID),
 		Accept:      aws.String("application/json"),
 		ContentType: aws.String("application/json"),
 	}
diff --git a/relay/adaptor/aws/utils/consts.go b/relay/adaptor/aws/utils/consts.go
new file mode 100644
index 00000000..c91f342e
--- /dev/null
+++ b/relay/adaptor/aws/utils/consts.go
@@ -0,0 +1,75 @@
+package utils
+
+import (
+	"context"
+	"slices"
+	"strings"
+
+	"github.com/songquanpeng/one-api/common/logger"
+)
+
+// CrossRegionInferences is a list of model IDs that support cross-region inference.
+//
+// https://docs.aws.amazon.com/bedrock/latest/userguide/inference-profiles-support.html
+//
+// document.querySelectorAll('pre.programlisting code').forEach((e) => {console.log(e.innerHTML)})
+var CrossRegionInferences = []string{
+	"us.amazon.nova-lite-v1:0",
+	"us.amazon.nova-micro-v1:0",
+	"us.amazon.nova-pro-v1:0",
+	"us.anthropic.claude-3-5-haiku-20241022-v1:0",
+	"us.anthropic.claude-3-5-sonnet-20240620-v1:0",
+	"us.anthropic.claude-3-5-sonnet-20241022-v2:0",
+	"us.anthropic.claude-3-7-sonnet-20250219-v1:0",
+	"us.anthropic.claude-3-haiku-20240307-v1:0",
+	"us.anthropic.claude-3-opus-20240229-v1:0",
+	"us.anthropic.claude-3-sonnet-20240229-v1:0",
+	"us.meta.llama3-1-405b-instruct-v1:0",
+	"us.meta.llama3-1-70b-instruct-v1:0",
+	"us.meta.llama3-1-8b-instruct-v1:0",
+	"us.meta.llama3-2-11b-instruct-v1:0",
+	"us.meta.llama3-2-1b-instruct-v1:0",
+	"us.meta.llama3-2-3b-instruct-v1:0",
+	"us.meta.llama3-2-90b-instruct-v1:0",
+	"us.meta.llama3-3-70b-instruct-v1:0",
+	"us-gov.anthropic.claude-3-5-sonnet-20240620-v1:0",
+	"us-gov.anthropic.claude-3-haiku-20240307-v1:0",
+	"eu.amazon.nova-lite-v1:0",
+	"eu.amazon.nova-micro-v1:0",
+	"eu.amazon.nova-pro-v1:0",
+	"eu.anthropic.claude-3-5-sonnet-20240620-v1:0",
+	"eu.anthropic.claude-3-haiku-20240307-v1:0",
+	"eu.anthropic.claude-3-sonnet-20240229-v1:0",
+	"eu.meta.llama3-2-1b-instruct-v1:0",
+	"eu.meta.llama3-2-3b-instruct-v1:0",
+	"apac.amazon.nova-lite-v1:0",
+	"apac.amazon.nova-micro-v1:0",
+	"apac.amazon.nova-pro-v1:0",
+	"apac.anthropic.claude-3-5-sonnet-20240620-v1:0",
+	"apac.anthropic.claude-3-5-sonnet-20241022-v2:0",
+	"apac.anthropic.claude-3-haiku-20240307-v1:0",
+	"apac.anthropic.claude-3-sonnet-20240229-v1:0",
+}
+
+// ConvertModelID2CrossRegionProfile converts the model ID to a cross-region profile ID.
+func ConvertModelID2CrossRegionProfile(model, region string) string {
+	var regionPrefix string
+	switch prefix := strings.Split(region, "-")[0]; prefix {
+	case "us", "eu":
+		regionPrefix = prefix
+	case "ap":
+		regionPrefix = "apac"
+	default:
+		// not supported, return original model
+		return model
+	}
+
+	newModelID := regionPrefix + "." + model
+	if slices.Contains(CrossRegionInferences, newModelID) {
+		logger.Debugf(context.TODO(), "convert model %s to cross-region profile %s", model, newModelID)
+		return newModelID
+	}
+
+	// not found, return original model
+	return model
+}